CryoElectron microscopy

Cryo-electron microscopy (Cryo-TEM or Cryo-EM) is the next evolution step of Electron Microscopy:

  • unaltered by drying in vacuum imaging, unlike conventional TEM

  • fast specimen freeze coverts water into transparent ice crystals

  • ice crystal transforms biomolecules in a rigid state allowing high-resolution imaging

  • sub 10 Å resolution (1 nm) allows imaging near-atomic structures

  • quick-fire imaging allows using a high power beam of 200 kV.