TFF

We offer Tangential Flow Filtration (TFF) services and application development for isolation, purification and concentration of target particles, product or biomolecules:
• Efficient separation and purification: TFF allows for the separation and purification of proteins, peptides, nucleic acids, and other biomolecules from complex mixtures like cell culture media or lysates.
• Gentle processing: TFF operates at low transmembrane pressure, allowing for gentle separation of sensitive biomolecules with minimal shear stress.
• High yields: TFF typically produces higher yields of small extracellular vesicles (sEVs) compared to ultracentrifugation methods
• Scalability: TFF systems can be easily scaled from proof of concept to pilot and industrial-scale, maintaining consistent parameters.
• Versatility: TFF can be used for concentration, diafiltration, buffer exchange, clarification, and depyrogenation in various bioprocessing steps.
• Continuous operation: The tangential flow allows for continuous filtration and reproducible performance.
• Compatibility with sensitive materials: TFF is suitable for processing shear-sensitive substances like certain enzymes and proteins.
• Application in emerging therapies: we offer TFF for cell and gene therapy production, viral vector manufacturing, and vaccine purification.
• Time and cost efficiency: Compared to traditional methods like ultracentrifugation, TFF often offers advantages in processing time and overall costs, especially for large-scale applications.
These benefits make tangential flow filtration a valuable technique in our biological and biomedical research services, as well as in biopharmaceutical manufacturing processes.